Articles: critical-illness.
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Comparative Study
Arterial or mixed venous lactate measurement in critically ill children. Is there a difference?
Seven critically ill children had simultaneous measurement of whole blood lactate concentrations obtained from a systemic arterial and mixed venous (pulmonary artery) site. An excellent correlation was found (r = 0.995). The mean difference between arterial and mixed venous values was 0.02 mmol/l and the limits of agreement (+/- 0.22) were -0.20 to 0.24. The differences found were clinically insignificant (two-tailed paired Student's t-test; p = 0.36) and therefore support the continued use of arterial sampling for blood lactate measurement.
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The objective of this study was to identify the underlying causes of respiratory-related critical events associated with intravenous patient-controlled analgesia (i.v. PCA). ⋯ Following review of the critical events, it was determined that the design of the PCA device contributed to the misprogramming errors and the device was removed from service. Changes in the training of physicians and nurses were instituted to avoid recurrence of other errors identified. The incidence of serious respiratory-related critical events was 0.1%. i.v. PCA therapy has the risk of potentially serious complications and requires constant physician and nursing care with an active quality assurance program.