Articles: anesthetics.
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Multicenter Study Clinical Trial
Monitoring depth of anesthesia utilizing a combination of electroencephalographic and standard measures.
For decades, monitoring depth of anesthesia was mainly based on unspecific effects of anesthetics, for example, blood pressure, heart rate, or drug concentrations. Today, electroencephalogram-based monitors promise a more specific assessment of the brain function. To date, most approaches were focused on a "head-to-head" comparison of either electroencephalogram- or standard parameter-based monitoring. In the current study, a multimodal indicator based on a combination of both electro encephalographic and standard anesthesia monitoring parameters is defined for quantification of "anesthesia depth." ⋯ A multimodal integration of both standard monitoring and electroencephalographic parameters may more precisely reflect the level of anesthesia compared with monitoring based on one of these aspects alone.
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Randomized Controlled Trial Multicenter Study
Lidocaine/tetracaine peel in topical anesthesia prior to laser-assisted hair removal: Phase-II and Phase-III study results.
Patient comfort is essential during dermatologic procedures. ⋯ After a 30-min application, LT peel was effective and well-tolerated in providing anesthesia for laser-assisted hair removal.
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Randomized Controlled Trial Multicenter Study
The effects of 2 µg and 4 µg doses of dexmedetomidine in combination with intrathecal hyperbaric bupivacaine on spinal anesthesia and its postoperative analgesic characteristics.
To compare the postoperative analgesic characteristics and side effects of two different doses of intrathecal dexmedetomidine in combination with hyperbaric bupivacaine, and to evaluate the effects of these combinations on spinal anesthesia. ⋯ Two different doses of dexmedetomidine, an α2-adrenoceptor agonist with analgesic effects, resulted in an increased duration of analgesia and efficacy, decreased postoperative analgesic use and was associated with no notable adverse effects.
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Multicenter Study Comparative Study
Audit of medication errors by anesthetists in North Western Nigeria.
Safety issues are an important aspect of anesthesia practice. The relevance of medication and drug administration errors in our everyday practice is an important aspect of medical audit. Although there have been few case reports of drug administration errors by anesthetists, there is paucity of information regarding medication errors in anesthetic practice in Nigeria. We set out to study the incidence of medication errors among anesthesia practitioners in Kaduna State, North Western Nigeria and to suggest ways to minimize such errors. ⋯ Medication errors do occur in the everyday practice of anesthetists in Nigeria as in other countries and can lead to morbidity and mortality in our patients. Routine audit and reporting of critical incidents including errors in drug administration should be encouraged. Reduction of medication errors is an important aspect of patient safety, and vigilance remains the watchword.
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Randomized Controlled Trial Multicenter Study Comparative Study
Comparison of the Potency of Different Propofol Formulations: A Randomized, Double-blind Trial Using Closed-loop Administration.
Different propofol formulations demonstrate different potencies when not mixed with lignocaine, but are similar when lignocaine is mixed.
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