Articles: anesthetics.
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Comparative Study Clinical Trial
Comparison of local anaesthetic techniques in the reduction of Colles' fracture.
A trial comparing the use of Bier's block and the direct infiltration of the fracture site with local anaesthetic was carried out to assess their effectiveness in the reduction of Colles' fracture. This showed Bier's block to be superior in terms of patient acceptability and in ease of reduction. The results of the reduction were also significantly better using the Bier's block, as judged by the measurement of the residual displacement on the X-ray.
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The in vitro sensitivities to local anaesthetic blockade of A, B and C nerve fibres in rabbit vagus nerves were examined using a series of structurally similar amino-ester agents which varied in lipid solubility and anaesthetic potency. A fibres were found to be the most sensitive and C fibres the least sensitive to conduction blockade with all the agents, provided that equilibrium blockade was allowed to develop. A correlation existed between the intrinsic anaesthetic potency of the various agents and their lipid solubilities. ⋯ As lipid solubility decreased through the series studied, so the onset of conduction blockade of A fibres was prolonged. It is suggested that this related to decreasing ability to penetrate the lipid diffusion barriers around A fibres. The traditional view that C fibres were more sensitive to block may have arisen because of confusion between absolute sensitivity and rate of development of conduction blockade.
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A patient who exhibited a severe reaction to an intravenous agent on one occasion was given a similar anaesthetic on a subsequent occasion without incident. Intradermal testing was carried out and the results are tabulated and discussed.