Articles: anesthetics.
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Malignant hyperthermia is a relatively rare condition which strikes susceptible patients undergoing surgery. This disorder is an inherited biochemical defect, triggered by certain anesthetic agents and stress. ⋯ If a patient, by family history or test, is suspected of being susceptible to malignant hyperthermia, special precautions must be taken before proceeding with surgery. The clinical engineer must: 1) prepare special anesthesia equipment which is free of trace gases capable of triggering an episode of malignant hyperthermia; 2) provide special monitoring facilities to detect the onset of an episode; and 3) have treatment facilities on hand in the event that an episode does develop.
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Anesthesia and analgesia · Sep 1982
Comparative StudyComparative cardiovascular effects of midazolam and thiopental in healthy patients.
Midazolam, a water-soluble benzodiazepine that is shorter-acting, more potent, and less irritating to veins than diazepam, has been suggested for use for induction of anesthesia. The cardiovascular effects of an induction-sized dose (0.25 mg/kg) of midazolam in A. S. ⋯ Midazolam is, then, as acceptable for induction of anesthesia as thiopental from a hemodynamic point of view in A. S. A. class I and II patients.
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Randomized Controlled Trial Comparative Study Clinical Trial
Haemodynamic effects of midazolam and thiopentone during induction of anaesthesia for coronary artery surgery.
The cardiovascular effects of thiopentone 3 mg kg-1 and midazolam 0.3 mg kg-1 were observed during induction of anaesthesia in 16 premedicated patients about to undergo myocardial revascularization. There were no significant changes in either group in cardiac output or central venous pressure. The heart rate in both groups showed an increase at 3 min and thereafter returned to control values. After 3 min, there was a significant decrease in both arterial pressure and peripheral resistance by 12% and 15% (mean values) respectively from control values in the group receiving midazolam, whereas after thiopentone the peripheral resistance increased by approximately 13% and was not affected by a further dose of thiopentone 1 mg kg-1.