Articles: anesthetics.
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Randomized Controlled Trial Comparative Study Clinical Trial
ICI 35868 (Diprivan): a new intravenous anaesthetic. A comparison with Althesin.
ICI 35868 (Diprivan), 1-2 mg/kg was used to induce anaesthesia in 20 patients, and the results compared with induction of anaesthesia by Althesin 0.5 ml/kg given to a similar group of 20 patients. ICI 35868 was effective in inducing anaesthesia, but produced more respiratory depression, and cardiovascular effects which were significantly different from those produced by Althesin. ICI 35868 gave a smoother induction. It is concluded that ICI 35868 is a promising new induction agent which may also find application for the maintenance of anaesthesia.
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The differential sensitivities of mammalian nerve fibers to various local anesthetic agents were investigated. Lidocaine, tetracaine, etidocaine, and bupivacaine demonstrated a consistent pattern of conduction blockade in which the large fast-conducting A fibers were blocked at the lowest drug concentration, the intermediate B fibers were blocked at a higher drug concentration, and the smallest, slowest-conducting C fibers required the highest drug concentration for conduction blockade. ⋯ These findings indicate that local anesthetic agents are similar to other biological stress modalities in terms of their differential effects on nerve fibers of various sizes and conduction velocities, i.e., the large fast-conducting fibers are more susceptible to conduction blockade than are the smaller, slower-conducting fibers. Discrepancies between results of this study and previous reports in the literature are discussed.
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Fluoroscopically controlled intra-articular facet joint block is a reliable method of diagnosing low back pain and sciatica caused by lumbar facet arthropathy. Of 20 patients studied, 13 had complete and immediate relief of pain, confirming the diagnosis, Six patients have been free of pain for more than six months following a single facet joint block with injection of a local anesthetic and corticosteroid suspension. Preliminary findings suggest that computed tomography has an important role in diagnosing symptomatic facet arthropathy.
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Lumbar facet arthropathy is an important cause of low back pain and sciatica. Intra-articular facet block can confirm symptomatic facet joint disease. Good understanding of the anatomy of the joint and fluoroscopic control are essential for intra-articular placement of anesthetics and steroids.
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Biull Eksp Biol Med · Nov 1980
Comparative Study[Histomorphologic assessment of the effectiveness of anesthesia during tooth preparation].
The efficacy of conduction anesthesia with 2% solutions of novocain, celnovocain, trimecain, lidocain during the preparation of teeth for metal crowns was studied in experiments on 16 dogs by neurohistological and histochemical examination of the Gasserian and superior cervical ganglions, the nodose ganglion, teeth and pericoronal tissues. It was established that in terms of the degree of anesthesia efficacy increase, the test anesthetics can be arranged as follows: novocain, celnovocain, trimecain, lidocain.