Articles: anesthetics.
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The transformation of lymphocytes in response to phytohemagglutinin stimulation was investigated in 77 patients undergoind anesthesia with and without coincident surgical operation. A depression of lymphocyte transformation apparent immediately following major operations was related primarily to the extent of tissue trauma and not to the anesthetic agent or technique. No depression of lymphocyte transformation followed anesthesia for treatment of pain or for minor operations. ⋯ The leukocyte count did not increase after comparable operations performed with regional anesthesia. Postoperative depression of lymphocyte transformation is primarily due to nonspecific stress, perhaps because of associated sympathetic and adrenocortical stimulation. The depressant effect of anesthesia alone is minimal.
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Z Geburtshilfe Perinatol · Oct 1975
Case Reports[Perinatal deaths associated with paracervical anesthesia (author's transl)].
Two infants' death associated with paracervical anesthesia are reported. In both cases a severe fetal bradycardia which developed 5 and 10 minutes, respectively, after paracervical injection of 10 ml of 0.5% Bupivacain, was the reason for Caesarean section. The clinical signs of the infants were similar: low Apgar score, primary apnea, grey colour, flaccidity, no reactions; after a few hours, however, general muscular hypertonus, and repeated attacks of tonic seizures. Accidental injection of Bupivacain into the fetus cannot be excluded in both cases. -- The fetal risks through paracervical anesthesia are being reviewed.
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Northwest dentistry · Sep 1975
Historical ArticleSome historical notes on the development of anesthetics.
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Minerva anestesiologica · Sep 1975
Randomized Controlled Trial Clinical Trial[Experimental design for the evaluation of intravenous anesthetics in man].