Articles: brain-injuries.
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Journal of neurotrauma · Jul 1997
Interleukin-6 and interleukin-10 in cerebrospinal fluid after severe traumatic brain injury in children.
Cytokines may play an important role in the pathophysiology of traumatic brain injury (TBI) in children. Interleukin-6 (IL-6) is a proinflammatory cyotkine that plays a role in regenerative processes within the central nervous system (CNS), whereas interleukin-10 (IL-10) is an antiinflammatory cytokine. Both have been measured in serum and cerebrospinal fluid (CSF) as an index of the degree of inflammation in diseases, including sepsis and meningitis. ⋯ Increased IL-10 concentrations were independently associated with age < 4 years and mortality (p = 0.004 and 0.04, respectively, multivariate linear model). This study demonstrates that IL-6 is increased after TBI in children to levels similar to those reported in adults and is the first to show that IL-10 is increased in CSF of humans after TBI. These data suggest that there may be an age-dependent production of IL-10 after TBI in children.
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Am J Phys Med Rehabil · Jul 1997
Incidence of fever in the rehabilitation phase following brain injury.
There appears to be a high incidence of fever after brain injury. The most common cause for fever is infection. The incidence of fever occurring as a result of hypothalamic thermoregulatory dysfunction after brain injury is less clear. ⋯ Twenty-four percent of subjects experienced fevers, with each of the populations having similar occurrence rates. Unexplained fever events were found in the traumatic brain injury (7%) and aneurysmal subarachnoid hemorrhage (8%) subpopulations only. No unexplained fever event was associated with a temperature greater than 100.8 degrees F.
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The aim of this study was to identify, in (pre-) clinically obtained data, parameters predicting the outcome of patients with multiple trauma and severe head injury. Fifty-eight patients aged 27 +/- 10 years were investigated an average of 5.8 years after the accident. The Hanover Polytrauma Score was 34 +/- 11 points, the initially assessed Glasgow Coma Scale (GCS) was 6.2 +/- 3.2 points; and the duration of coma was 15.4 +/- 14.4 days. ⋯ Some 42% of all patients had taken up their former profession, 5% were still in training or at college, 32% were retrained to other professions, 16% were unemployed and 5% were completely retired on pension. Age, injury severity, GCS, duration of coma and duration of weaning were suitable predictors in correlation- and regression analysis. The Glasgow Outcome Scale showed good recovery and moderate disability in 53%, severe disability in 33% and persistent vegetative state in 14% of the patients.
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Motor vehicle-related accidents account for the largest number of head injuries in all ages. This article reviews types of injury, neurologic assessment, secondary injury, brain swelling, seizures, resuscitation, and intensive care.
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Critical care medicine · Jul 1997
Clinical TrialDose response, recovery, and cost of doxacurium as a continuous infusion in neurosurgical intensive care unit patients.
To determine the optimal dosing of doxacurium as a continuous infusion in neurosurgical patients with traumatic brain injury; to determine the effects of bolus administration of doxacurium on heart rate (HR), blood pressure (BP), and intracranial pressure (ICP); to monitor neuromuscular recovery after discontinuation of prolonged doxacurium infusion; and to compare the cost of doxacurium with other current neuromuscular blocking drugs. ⋯ Continuous infusion of doxacurium provides stable neuromuscular blockade for neurosurgical patients with traumatic brain injury. Doxacurium is devoid of clinically important interactions with HR, BP, or ICP and is less costly than other neuromuscular blockers used in the ICU.