Articles: brain-injuries.
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J Neurosurg Anesthesiol · Jul 1996
Case ReportsConventional multimodality monitoring and failure to detect ischemic cerebral blood flow.
We report a case of cerebral infarction following traumatic brain injury associated with low cerebral blood flow, but not detected by measurements of jugular venous oxygen saturation, cerebral lactate production, cerebral perfusion pressure, transcranial Doppler ultrasound, or measures of systemic hemodynamics.
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Randomized Controlled Trial Multicenter Study Clinical Trial
The safety, tolerability, and pharmacokinetics of fosphenytoin after intramuscular and intravenous administration in neurosurgery patients.
To evaluate the safety, tolerability, and pharmacokinetic profile of fosphenytoin, a water-soluble phenytoin prodrug, after intramuscular and intravenous administration. ⋯ Fosphenytoin can be administered intramuscularly and intravenously in neurosurgical patients to achieve and maintain therapeutic phenytoin concentrations for up to 14 days. Both routes are safe and well tolerated. Intravenous fosphenytoin is significantly better tolerated than intravenous phenytoin sodium in this patient subset.
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The purpose of this research utilization article is to familiarize cardiovascular nurses with the Brain Resuscitation Clinical Trials (BRCTs) I and II and discuss the application of these trials to nursing practice. The BRCTs are a series of studies that examine the effects of selected interventions on neurologic outcome after cardiac arrest.