Article Notes

• Hide
  • Pearls
  • Summaries
  • Comments

pearl
1
Dexamethasone does not affect sugammadex neuromuscular reversal in children.
Gulec E, Biricik E, Turktan M et al. The Effect of Intravenous Dexamethasone on Sugammadex Reversal Time in Children Undergoing Adenotonsillectomy. Anesth. Analg. 2016 Apr 1; 122 (4): 1147-52.
  Daniel Jolley
comment
1
Sounds like a promising drug but will we be able to afford it!
Pollack CV, Reilly PA, Eikelboom J et al. Idarucizumab for Dabigatran Reversal. N. Engl. J. Med. 2015 Aug 6;373(6):511-20.
  Allan Palmer
comment
0
1mcg/kg fentanyl as sole intraoperative analgesic is less than most instutions would administer and may explain a high baseline postoperative agitation rate.
Abdulatif M, Ahmed A, Mukhtar A et al. The effect of magnesium sulphate infusion on the incidence and severity of emergence agitation in children undergoing adenotonsillectomy using sevoflurane anaesthesia. Anaesthesia. 2013 Oct 1;68(10):1045-52.
  Pieter Peach
pearl
1
Routine lorazepam premedication before surgery does not improve patient experience but does prolong time to extubation, even among anxious patients.
Maurice-Szamburski A, Auquier P, Viarre-Oreal V et al. Effect of sedative premedication on patient experience after general anesthesia: a randomized clinical trial. JAMA. 2015 Mar 3;313(9):916-25.
  Daniel Jolley
pearl
0
Intraoperative dexamethasone for antiemesis does not appear to significantly alter glucostasis during the first 24 post-operative hours in non-diabetic patients.
Murphy GS, Szokol JW, Avram MJ et al. The Effect of Single Low-Dose Dexamethasone on Blood Glucose Concentrations in the Perioperative Period: A Randomized, Placebo-Controlled Investigation in Gynecologic Surgical Patients. Anesth. Analg. 2014 Jun 1;118(6):1204-12.
  Daniel Jolley
pearl
1
Maintaining anesthesia with either sevoflurane or propofol for laparoscopic gynaecology surgery has no differential effect on post-operative pain.
Pokkinen SM, Yli-Hankala A, Kalliomäki ML. The effects of propofol vs. sevoflurane on post-operative pain and need of opioid. Acta Anaesthesiol Scand. 2014 Sep 1; 58 (8): 980-5.
  Daniel Jolley
comment
2
Great to see a new agent in the pipeline but why oh why use BIS as an endpoint as by definition BIS has never been calibrated against the new agent.
Monagle J, Siu L, Worrell J et al. A Phase 1c Trial Comparing the Efficacy and Safety of a New Aqueous Formulation of Alphaxalone with Propofol. Anesth. Analg. 2015 Oct 1; 121 (4): 914-924.
  Allan Palmer
comment
1
If what you are currently doing works for you keep doing it. If it doesn't, use hyperbaric!
Sia AT, Tan KH, Sng BL et al. Use of hyperbaric versus isobaric bupivacaine for spinal anaesthesia for caesarean section. Cochrane Db Syst Rev. 2013 Jan 1;5:CD005143.
  Allan Palmer
pearl
1
Phaxan™, an alphaxalone-cyclodextrin preparation offers fast-onset & short-duration anesthesia equivalent to propofol without pain on injection and with less hypotension.
Monagle J, Siu L, Worrell J et al. A Phase 1c Trial Comparing the Efficacy and Safety of a New Aqueous Formulation of Alphaxalone with Propofol. Anesth. Analg. 2015 Oct 1; 121 (4): 914-924.
  Daniel Jolley
pearl
1
Postoperative delirium is a risk factor for developing post traumatic stress disorder (PTSD) in elderly patients after surgery and hospital stay.
Drews T, Franck M, Radtke FM et al. Postoperative delirium is an independent risk factor for posttraumatic stress disorder in the elderly patient: A prospective observational study. Eur J Anaesthesiol. 2015 Mar 1;32(3):147-51.
  Daniel Jolley