• Acta Medica Port · Jul 2020

    Review

    Medicines for the Treatment Of COVID-19: Awaiting the Evidence.

    • Natalia Marto and Emília C Monteiro.
    • Chronic Diseases Research Centre (CEDOC,). NOVA Medical School. Faculdade de Ciências Médicas. Universidade NOVA de Lisboa. Lisboa. Department of Internal Medicine. Hospital da Luz. Lisboa. Portugal.
    • Acta Medica Port. 2020 Jul 1; 33 (7-8): 500-504.

    AbstractThe novel severe acute respiratory syndrome coronavirus 2 is the cause of Coronavirus Disease 2019, a new illness with no effective treatment or vaccine that has reached pandemic proportions. In this document, we analyze how health authorities and agencies around the world position themselves regarding the off-label use of repurposed drugs or new investigational drugs to treat Coronavirus Disease 2019. We review the most promising candidate medicines, including available evidence, clinical recommendations and current options for access. Our concluding remarks stress the importance of administering off-label and investigational drugs in the setting of clinical trials, or at least in standardized scenarios, to generate as much scientific knowledge as achievable while engaging in the best efforts to treat patients and save lives.

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