• Arch Iran Med · Jan 2019

    Reference Values for Serum Lipid Profiles in Iranian Adults: Tehran Lipid and Glucose Study.

    • Maryam Rahmani, Sajad Jeddi, Mahboubeh Ghanbari, Amir Abbas Momenan, Fereidoun Azizi, and Asghar Ghasemi.
    • Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
    • Arch Iran Med. 2019 Jan 1; 22 (1): 24-31.

    BackgroundLipid abnormalities are major risk factors for cardiovascular diseases. In addition to age and sex, other variables can affect serum lipid levels, warranting the determination of population-specific reference values. This study aimed to determine age- and sex-specific reference values for serum total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C), high-density lipoprotein-cholesterol (HDL-C), and triglycerides (TG) in healthy Tehranian adults.MethodsTC, TG, and HDL-C were measured using the enzymatic colorimetric method and the Friedewald equation (LDL-C = TC - HDL-C - TG/5) was used to calculate LDL-C concentrations in individuals with TG <400 mg/dL. After applying the exclusion criteria, 1147 participants (548 men and 599 women) aged ≥20 years were included. For determining reference values, the International Federation of Clinical Chemistry guidelines (non-parametric method) and the robust method were used for sample sizes ≥120 and <120, respectively.ResultsReference values for serum TC, LDL-C, HDL-C, and TG were 121.0-261.0, 54.1-175.2, 30.9-71.9, and 46.9-301.2 mg/ dL in men and 117.8-235.9, 49.9-160.9, 36.0-83.9, and 38.1-184.2 mg/dL in women, respectively. All parameters except HDL-C were higher in men than women and showed an increasing trend with age.ConclusionReference values for serum TC, LDL-C, HDL-C, and TG in healthy Tehranian adults were determined, and these values could provide the basis for better decision making in both prevention and clinical settings.© 2019 The Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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