• Arch Iran Med · Apr 2020

    Review

    Impact of War on Fertility and Infertility.

    • Ayeh Bolouki and Fatemeh Zal.
    • Biochemistry Department, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
    • Arch Iran Med. 2020 Apr 1; 23 (4Suppl1): S16-S22.

    BackgroundWar causes more death and disability than many major diseases. There are few studies in the context of the deleterious impact of war on fertility potential; therefore, in this study, we tried to review articles about the adverse effects of war on male/ female fertility potential.MethodsIn this study, a total of 183 articles related to the effects of war on fertility potential were examined by a systematic search using known international medical databases.ResultsAmong these studies, there were limited studies on the effects of war on female infertility and most studies examined the effects of war on sperm parameters and male infertility. The physical and psychological trauma of war can increase the risk of infertility in men and women. Presence of reproductive system toxins in weapons, stressful periods of war and direct damage to the reproductive system can impair the fertility of men and women. The way war affects male fertility is not clear, but the higher degree of stress during wartime seems to play an important role. Using reproductive toxicants during the war also increases the risk of impairment in reproductive function in men. Some studies have shown the harmful effects of Sulfur mustard as a war chemical toxin especially on sperm quality and male infertility. Oxidative stress induced by free radicals is a major mechanism for the direct effects of Sulfur mustard on male infertility.ConclusionThe study of past research suggests that exposure to war may be an independent risk factor for reproductive disorders and infertility in men. For female infertility, war leads to menstrual dysfunction.© 2020 The Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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