• Benjamard Thaweethee-Sukjai, Sirijit Suttajit, Samur Thanoi, Caroline F Dalton, Gavin P Reynolds, and Sutisa Nudmamud-Thanoi.
• Department of Anatomy, Faculty of Medical Science, Naresuan University, Phitsanulok, 65000, Thailand.
• Int J Med Sci. 2019 Jan 1; 16 (9): 1207-1214.

AbstractAims: To determine the extent of DNA methylation of parvalbumin gene (PVALB) promoter in major depressive disorder (MDD) patients with and without suicide attempt in comparison with healthy controls. Methods: The extracted DNA from dried blood spots of MDD patients (n = 92) including non-suicidal MDD and suicidal-MDD subgroups (n = 45 and n = 47, respectively) and age-matched control subjects (n = 95) was used for DNA methylation analysis at four CpG sites in the promoter sequence of PVALB by pyrosequencing. Results: The PVALB methylation was significantly increased at CpG2 and decreased at CpG4 in the MDD group compared to the control group, while there was no difference between non-suicidal MDD and suicidal-MDD subgroups. A significant inverse correlation of severity of MDD was indicated only for CpG4. Conclusion: This study provides the first evidence of abnormalities of PVALB promoter methylation in MDD and its correlation with MDD severity indicating a role for epigenetics in this psychiatric disorder.© The author(s).

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