• Qian Wang, Shengnan Jia, Yan Jiao, Libo Xu, Ding Wang, Xuyang Chen, Xindan Hu, Hang Liang, Naiyan Wen, Shengnan Zhang, Baofeng Guo, and Ling Zhang.
• Department of Pathophysiology, College of Basic Medical Science, Jilin University, Changchun 130021, P. R. China.
• Int J Med Sci. 2019 Jan 1; 16 (12): 1573-1582.

AbstractColorectal cancer is one of the most common cancers worldwide with a high incidence rate. Therefore, the molecular basis of colorectal tumorigenesis and evolution must be clarified. Structure-specific recognition protein 1 (SSRP1) is involved in transcriptional regulation, DNA damage repair, and cell cycle regulation and has been confirmed to be highly expressed in various tumor tissues, including colorectal cancer. However, the role of SSRP1 in the development of colorectal cancer remains unclear. Therefore, this study explored the role of SSRP1 in the occurrence and development of colorectal cancer. Using bioinformatics databases, including samples from the Cancer Genome Atlas (TCGA), we confirmed high SSRP1 expression in human colorectal adenocarcinoma tissues. We demonstrated that SSRP1 knockdown via small interfering RNA significantly inhibited the proliferation of colorectal cancer cells and promoted apoptosis through the AKT signaling pathway, suppressing the invasion and migration of colorectal cancer cells in vitro and in vivo. In conclusion, this study demonstrated that SSRP1 silencing influenced the proliferation and apoptosis of colorectal cancer cells via the AKT signaling pathway.© The author(s).

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