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- Nan Zhou, Yun Zhang, Jin-Chun Zhang, Ling Feng, and Jin-Ku Bao.
- School of Life Sciences & Key Laboratory of Bio-resources, Ministry of Education, Sichuan University, Chengdu 610064, China.
- J Formos Med Assoc. 2014 Mar 1; 113 (3): 143-7.
AbstractThe newly emerged Middle East respiratory syndrome coronavirus (MERS-CoV) is becoming another "SARS-like" threat to the world. It has an extremely high death rate (∼50%) as there is no vaccine or efficient therapeutics. The identification of the structures of both the MERS-CoV receptor binding domain (RBD) and its complex with dipeptidyl peptidase 4 (DPP4), raises the hope of alleviating this currently severe situation. In this review, we examined the molecular basis of the RBD-receptor interaction to outline why/how could we use MERS-CoV RBD to develop vaccines and antiviral drugs.Copyright © 2013. Published by Elsevier B.V.
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