• Hou-Chiang Chou, Han-Wei Lin, Ju-Hsuan Yang, Ping-Yi Lin, Shih-Jung Cheng, Yu-Hsueh Wu, and Ying-Shiung Kuo.
• Department of Dentistry, Far Eastern Memorial Hospital, New Taipei City, Taiwan.
• J Formos Med Assoc. 2019 Dec 1; 118 (12): 1616-1622.

Background/PurposeOral cancer patients who survive for more than 5 years are supposed to have a reduced local cancer recurrence rate and survive longer. This study evaluated whether oral cancer patients who survived for more than 5 years might have reduced rates of local cancer recurrence, development of the second or third primary oral cancer, or the late regional cervical lymph node metastasis.MethodsThis study analyzed the clinical outcomes of 127 oral cancer patients (101 men and 26 women; mean age, 50.8 ± 12.1 years) who survived for more than 5 years after proper treatments of the initial primary oral cancers.ResultsThe 127 primary oral cancers included 117 squamous cell carcinomas (SCCs), 7 mucoepidermoid carcinomas, and 3 others. Of the 127 oral cancer patients who survived for more than 5 years, 47 survived for 5-9 years, 45 for 10-14 years, 22 for 15-19 years, 10 for 20-24 years, two for 25-29 years, and one for 30 years. Ten patients had local cancer recurrence 5.4 years-13.7 years, 12 patients had a second or a third primary oral cancer 3.6 years-17.2 years, and one mucoepidermoid carcinoma patient had a late regional cervical lymph node metastasis 11.9 years after total excision of the initial primary oral cancers.ConclusionOral cancer patients who survive for more than 5 years may still have local cancer recurrence, the second or third primary oral cancer, or the late regional cervical lymph node metastasis but with a reduced rate.Copyright © 2019 Formosan Medical Association. Published by Elsevier B.V. All rights reserved.

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