• Marjan Oustad, Mohamadreza Najafi, Jafar Mehvari, Amin Rastgoo, Zahrasadat Mortazavi, and Mitra Rahiminejad.
• Department of Neurology, Medical School, Isfahan University of Medical Sciences, Isfahan, Iran.
• J Res Med Sci. 2020 Jan 1; 25: 29.

BackgroundCognitive impairment is a common complication of patients with temporal lobe epilepsy (TLE). Therefore, the aim of this study was to compare the effects of donepezil and memantine on improving the cognitive function of patients with TLE.Materials And MethodsIn a clinical trial study, 70 patients with TLE were divided into two groups of 35 each: 10 mg doses of donepezil (first group) and memantine (second group) were applied for 16 weeks. The level of cognitive function of patients in both groups before and after treatment was determined using Montreal Cognitive Assessment (MoCA) test.ResultsThe mean score of MoCA before and after intervention was 23.55 ± 3.67 and 26.09 ± 2.5, respectively, in the group treated with memantine, and the mean score of intervention was significantly improved (P < 0.001). In the group treated with donepezil, the score before and after the operation was 23.87 ± 3.18 and 24.35 ± 2.17, respectively, and no significant difference was observed in this group (P = 0.38).ConclusionHence, memantine was better than donepezil in the improvement of cognitive impairment in patients with TLE.Copyright: © 2020 Journal of Research in Medical Sciences.

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