• Medicina clinica · Mar 2020

    Observational Study

    Predictive factors of hyperglycaemia in patients with parenteral nutrition.

    • Cristina Sangrador Pelluz, Júlia Pardo Pastor, Elisabeth Navas Moya, Jordi Nicolás Picó, and Salvador Quintana.
    • Servicio de Farmacia, Hospital Universitario Mútua Terrassa, Terrasa, Barcelona, España. Electronic address: csangrador@mutuaterrassa.cat.
    • Med Clin (Barc). 2020 Mar 13; 154 (5): 157-162.

    ObjectiveTo identify the predictive factors of hyperglycaemia in patients receiving parenteral nutrition (PN).Material And MethodsRetrospective observational study (January 2016-December 2016) conducted in a 450-bed university hospital. Adult hospitalized patients who received total PN through a central line for at least 48hours were included. The required variables to characterize patients, and those related to the PN received were collected and hyperglycaemia was defined as 3 consecutive glycaemias greater than 150mg/dl or 2 greater than 180mg/dl. A descriptive, comparative bivariate statistical analysis was carried out, as well as a multivariate analysis using binary logistic regression (SPSS.v.24.) RESULTS: 234 patients were included. The prevalence of hyperglycaemia in the population under study was 44.0%. The main differences observed in the bivariate analysis between hyperglycaemic and normoglycemic patients were related to age, previous comorbidities, medical department, presence of sepsis, duration and glucose contribution in PN, as well as blood glucose levels and corticosteroids. The predictors of hyperglycaemia obtained after the multivariate analysis were: renal clearance (OR=.982, 95% CI .968-.996, P=.010), pre-PN glycaemia (OR=1.039, 95% CI 1.026-1.051, P<.001), diabetes mellitus (OR=11.016, 95% CI 3.028-31.697, P<.001), intensive medicine (OR=3.303, 95% CI 1.183-9.219, P=.023), corticosteroids (OR=3.155, 95% CI 1.179-8.226, P=.022).ConclusionsDecreased renal clearance, high blood glucose levels, diabetes, corticosteroid use, and critical patients are predictors of hyperglycaemia, therefore it would be advisable to consider them in the design of PN start formula.Copyright © 2019 Elsevier España, S.L.U. All rights reserved.

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