Effect of antiresorptive and bone forming treatments in bone

Medicina clinica · May 2020

Review

Effect of antiresorptive and bone forming treatments in bone erosions in rheumatoid arthritis.

Rheumatoid arthritis (RA) is a chronic inflammatory disease that can cause joint destruction and marked disability. Early treatment with disease-modifying drugs, including biological therapy, is the principal treatment to prevent the structural damage associated with this entity. Some studies have indicated that concomitant treatment with antiresorptives, such as bisphosphonates or denosumab, could prevent erosive lesions in this process, and it has even been suggested that treatment with a bone forming agent, such as teriparatide, could revert previously established erosive lesions. In this article we review the evidence available on the efficacy of treatment with antiresorptives and bone forming agents in the prevention and/or treatment of bone erosions associated with RA.

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- Ana Belén Azuaga-Piñango and Pilar Peris.
- Servicio de Reumatología, Hospital Clínic, Universidad de Barcelona, Barcelona, España. Electronic address: abazuaga@clinic.cat.
- Med Clin (Barc). 2020 May 8; 154 (9): 358-365.
AbstractRheumatoid arthritis (RA) is a chronic inflammatory disease that can cause joint destruction and marked disability. Early treatment with disease-modifying drugs, including biological therapy, is the principal treatment to prevent the structural damage associated with this entity. Some studies have indicated that concomitant treatment with antiresorptives, such as bisphosphonates or denosumab, could prevent erosive lesions in this process, and it has even been suggested that treatment with a bone forming agent, such as teriparatide, could revert previously established erosive lesions. In this article we review the evidence available on the efficacy of treatment with antiresorptives and bone forming agents in the prevention and/or treatment of bone erosions associated with RA.Copyright © 2020 Elsevier España, S.L.U. All rights reserved.

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Effect of antiresorptive and bone forming treatments in bone erosions in rheumatoid arthritis.

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