• Marta Illán Ramos, Diana Mazariegos Orellana, Luis M Prieto Tato, M Luisa Navarro Gómez, Eloy Muñoz Gálligo, and José Tomás Ramos Amador.
• Servicio de Pediatría, Hospital Clínico San Carlos, Madrid, España. Electronic address: marta.illan@salud.madrid.org.
• Med Clin (Barc). 2020 Nov 27; 155 (10): 441-444.

IntroductionThe risk of HIV-1 mother-to-child transmission (MTCT) is associated mainly with gestational age at which antiretroviral therapy begins and the HIV-1 RNA plasma viral load at delivery. Regimens with integrase inhibitors (INI) are increasing in high-risk pregnant women. The objective was to review the experience with INI in a Madrid Cohort of mother-infant pairs.Patients And MethodsRetrospective, multicentric, observational study, of HIV-infected pregnant women exposed to INI. Patients of 9 hospitals were included (2000-2017).ResultsSixty-seven pregnant women exposed to INI (cohort: 1,423) and 68 children (17.6% premature babies, 34.3% with combined postexposure prophylaxis). There were no cases of MTCT. Of 24 women with no previous antiretroviral therapy, 20 were diagnosed in current pregnancy. Of 43 women with antiretroviral therapy before pregnancy, 65% received INI before conception. Raltegravir was the most used (80.5%). There was a statistically significant increase (p = 0,02) of mothers with undetectable viral load at delivery. INI were well tolerated. In 11.7% of exposed children minor congenital anomalies were detected.ConclusionsINI seem safe and effective in the prevention of MTCT. Our findings support their use as intensification regimens in pregnant women with high risk of MTCT.Copyright © 2020 Elsevier España, S.L.U. All rights reserved.

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