• Alia Ali, Azeem Taj, Muhammed Uthman Ahmed, and Elsa Tabrez.
• Dr. Alia Ali, FCPS. Assistant Professor, Department of Medicine, Shaikh Zayed Postgraduate Medical Institute, Lahore, Pakistan.
• Pak J Med Sci. 2020 Mar 1; 36 (3): 407-411.

ObjectivesTo determine the frequency of impaired fasting glucose in first degree relatives of people with Type-II diabetes and its association with BMI.MethodsThis cross-sectional study was conducted in Diabetic clinic of Shaikh Zayed Hospital, Lahore from July to December 2017. Individuals aged ≥35 years, first degree relatives of people with Type-II diabetes, were selected and their fasting blood glucose levels were checked twice a week apart. Study participants were divided into 3 groups. Group-I were those with normal fasting blood glucose (FBS: <100mg/dl), Group-II were those with impaired fasting glucose (100-125mg/dl), considered as high risk and Group-III included those who turned out to be having frank diabetes (FBS: ≥126mg/dl). Exclusion criteria were known diabetes and pregnancy. Proportions of impaired fasting glucose levels versus BMI were compared using Chi-square test. Significance was considered at P <0.001.ResultsA total of hundred subjects were included in the study with the mean age of 44.27 years. Sixty percent participants had normal FBS, 31% showed impaired FBS and 09% had frank diabetes (P <0.001). Significant association was found between impaired fasting glucose and BMI, as with increasing BMI the frequency of impaired fasting glucose increases.ConclusionFirst-degree relatives of people with Type-II diabetes showed higher frequency of impaired fasting glucose and obesity was an important risk factor.Copyright: © Pakistan Journal of Medical Sciences.

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