• Rev Invest Clin · Jan 2019

    OXIDATIVE STRESS, TELOMERE LENGTH, AND FRAILTY IN AN OLD AGE POPULATION.

    • José D Martínez-Ezquerro, Aleida Rodríguez-Castañeda, Mauricio Ortiz-Ramírez, Sergio Sánchez-García, Haydee Rosas-Vargas, Rosalinda Sánchez-Arenas, and Paola García-de la Torre.
    • Human Genetics Medical Research Unit, Pediatrics Hospital, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City.
    • Rev Invest Clin. 2019 Jan 1; 71 (6): 393-401.

    BackgroundA global aging population requires focusing on the risk factors for unhealthy aging, preventive medicine, and chronic disease management. The identification of adverse health outcomes in older adults has been addressed by the characterization of frailty as a biological syndrome. In this field, oxidative stress and telomere length have been suggested as biomarkers of aging.ObjectiveThe objective of the study was to study the association of oxidative stress, telomere length, and frailty in an old age population.MethodsWe conducted a cross-sectional study based on 2015 data from 202 members of a cohort of older adults (n = 202; F/M gender ratio: 133/69; mean age: 69.89 ± 7.39 years). Reactive oxygen species were measured by dichlorofluorescein diacetate and lipid peroxidation by malondialdehyde. Telomere length was determined using quantitative polymerase chain reaction with SYBR Green Master Mix.ResultsStatistical analysis showed an association between telomere length and frailty but no association between oxidative stress and telomere length or frailty.ConclusionsTelomere length could eventually be used as a marker to differentiate between healthy and unhealthy aging as expressed by frailty phenotype; oxidative stress seemed merely a biological process of aging.Copyright: © 2019 Permanyer.

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