• Erick S Sánchez-Salguero, Brenda C Rodríguez-Chacón, Jorge Leyva-Daniel, Josué Zambrano-Carrasco, Carlos E Miguel-Rodríguez, and Leopoldo Santos-Argumedo.
• Department of Molecular Biomedicine, Center for Research and Advanced Studies, National Polytechnic Institute (CINVESTAV-IPN), Mexico City, Mexico.
• Rev Invest Clin. 2020 Jan 1; 72 (2): 80-87.

BackgroundSeveral studies have evaluated the effect of infectious diseases and vaccine protocols during pregnancy on maternal milk immunoglobulin (Ig) levels, to understand the protection conferred by lactation on newborns. Colostrum is the primary source of maternal IgA for the newborn. IgA participates in protection mechanisms in the neonate's mucosa. In humans, IgA has two subclasses with differential anatomical distribution among mucosal compartments. Total IgA levels in maternal milk vary after antigen stimulation and have differential affinities in function of the chemical composition of the antigens. We studied the effect of antigenic stimulation during pregnancy on the concentrations of specific IgA1 and IgA2 subclasses in human colostrum.MethodsWe analyzed data from 113 women in Mexico City and compared the amount of IgA subclasses in colostrum against three antigens: two from vaccine protocols (tetanus toxoid and pneumococcal polysaccharides) and lipopolysaccharide, a ubiquitous antigen in the gastrointestinal tract.ResultsIn agreement with the previous reports, we showed that IgA1 from colostrum mainly recognized protein antigens; in sharp contrast, IgA2 was mostly directed against polysaccharide antigens. These levels increased in women who had previous contacts through vaccination or infections during pregnancy.ConclusionsAntigen interaction during pregnancy increased the amount of specific IgA subclasses, depending on the chemical composition of the antigen.Copyright: © 2020 Permanyer.

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