• Alison E Lim, Paul Sooby, and Richard B Townsley.
• Foundation Doctor, Department of Otolaryngology, Head and Neck Surgery, Crosshouse University Hospital, Kilmarnock, NHS Ayrshire and Arran, UK.
• Scot Med J. 2020 May 1; 65 (2): 60-63.

AimTo present our national case series on primary thyroid squamous cell carcinoma (PTSCC) and add to the current literature about this rare and aggressive disease.MethodsScottish pathology departments were contacted and asked to provide details of patients with the diagnosis of PTSCC from the last 10 years. Three patients were included.ResultsPatients 1, 2 and 3 underwent surgical resection. Patients 1 and 3 went on to receive chemoradiotherapy. Patient 1 received nivolumab. Patient 1 died 10 months following diagnosis. Patient 2 and 3 are currently living with no recurrence, over two years post-diagnosis.ConclusionThis case series has demonstrated an unusually good set of outcomes for a classically rapidly progressing disease with poor survival rates. This raises the question whether there is a subgroup of PTSCC associated with better outcomes and lower mortality. A patient-centred approach will give optimal patient management.

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