• Nalan Metin Aksu, Duygu Yazgan Aksoy, Meltem Akkaş, Neşe Çinar, Fatma Uçar, Okan Bülent Yildiz, and Aydan Usman.
• Department of Emergency, Faculty of Medicine, Hacettepe University, Ankara, Turkey
• Turk J Med Sci. 2020 Apr 9; 50 (2): 312-315.

Background/AimAcute hyperglycemia is generally a frequently encountered condition in the emergency department (ED), because it is seen as a complication of diabetes mellitus (DM). In this study, we aimed to detect the change in adiponectin levels during acute hyperglycemic states and after normalization of blood glucose with insulin treatment.Materials And MethodsForty-eight patients over the age of 18 years who were admitted to the ED with acute hyperglycemia were included in the study. Serum samples were taken from patients on admission and 6 h after the normalization of blood glucose with insulin treatment, and adiponectin levels were measured in both samples.ResultsThere were 21 female and 27 male patients with a median age of 58.7 ± 18 years. All patients’ blood glucose levels were normalized with insulin treatment according to international recommendations. Serum adiponectin levels decreased significantly after the normalization of blood glucose in the whole group. Adiponectin levels decreased from 28.9 ± 16.5 to 12.1 ± 10.9 μg/mL (P < 0.0001) in the whole group. This decrease was independent of diabetes type and body mass index.ConclusionNormalization of blood glucose in patients with hyperglycemia caused a decrease in adiponectin levels, independent of diabetes type and/or body weight in an acute emergency setting. Inhibited upregulation of adiponectin secretion and/or blunted suppressive effect of insulin due to hyperglycemia or exogenous insulin administration may have caused the decrease in adiponectin levels.This work is licensed under a Creative Commons Attribution 4.0 International License.

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