• Sema Karakaş, Cihan Kaya, Hakan Güraslan, Damlanur Sakiz, Sema Süzen Çaypinar, Hüseyin Cengiz, Murat Ekin, and Levent Yaşar.
• Department of Obstetrics and Gynecology, University of Health Sciences,Gaziosmanpaşa Taksim Training and Research Hospital, İstanbul, Turkey
• Turk J Med Sci. 2020 Apr 9; 50 (2): 455463455-463.

Background/AimAdnexal torsion is a common gynaecological emergency, and considered to be a problem mostly in reproductive-age women. To evaluatethe effect of metformin and detorsion treatment on reducing ovarian reserve in an ovarian torsion model.Materials And MethodsTwenty-four nonpregnant, Wistar Hannover rats were included in the study. Animals were divided into 3 groups: the control group, the detorsion only group, and the metformin + detorsion group. The first group received only laparotomy. In the second group, ovaries were fixed to the abdominal wall after performing 360° ovarian torsion, followed by detorsion after a 3-h period of ischemia. The third group underwent the same torsion and detorsion procedures as the second group, and received 50 mg/kg metformin by gavage for 14 days. Ovarian damage scores, follicle counts, and AMH levels were evaluated.ResultsThe total damage score was significantly increased in the detorsion only group compared to the metformin+detorsion and control groups. Pre-operative/post-operative AMH decreases were statistically significant in negative direction in the detorsion only group when compared to the metformin+detorsion and control groups (P = 0.001).ConclusionMetformin+detorsion treatment may be effective in protecting the ovarian reserve after ovarian torsion.This work is licensed under a Creative Commons Attribution 4.0 International License.

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