• Özgür Korhan Tunçel, Gökhan Sarisoy, Eda Çetin, Ebru Kaynar Tunçel, Birşen Bilgici, and Arzu Karaustaoğlu.
• Medical Biochemistry Department, Faculty of Medicine, Ondokuz Mayıs University, Samsun,Turkey
• Turk J Med Sci. 2020 Jun 23; 50 (4): 985-993.

Background/AimNeurotrophins are one of the most important molecule groups affecting cerebral neuroplasticity. The amount of evidence about the role of changes in neuroplasticity in the pathophysiology of bipolar disease is growing.Materials And MethodsWe measured serum levels of brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), neurotrophin-3 (NT-3), glial cell-line derived neurotrophic factor (GDNF), vascular endothelial growth factor (VEGF), insulin-like growth factor-1 (IGF-1), fibroblast growth factor (FGF)-2, neuritin 1 (Nrn 1) in bipolar 1 manic episode patients (n = 45) and healthy control group.ResultsWhen controlled for age, BMI and cortisol, it was found that the serum levels of BDNF, NGF, NT-3, VEGF and FGF-2 of bipolar manic episode patients were not statistically different compared to those of the control group. GDNF level and Nrn 1 levels were significantly lower (P = 0.003 and P = 0.025 respectively) while IGF-1 levels were significantly higher than the control group (P = 0.0001). ROC analysis was performed and the area under the the curve was calculated as 0.737, 0.766 for GDNF, IGF-1 respectively.ConclusionThe changes in the levels of GDNF, IGF-1 and Nrn 1 might be involved in pathopysiology of bipolar disorder, and GDNF, IGF-1 may be considered as state markers in bipolar manic episode.This work is licensed under a Creative Commons Attribution 4.0 International License.

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