• Turk J Med Sci · Jun 2020

    Evaluation of the effects of ß1-selective beta-blockers on bone mineral density and fracture risk in postmenopausal women.

    • Betül Yavuz Keleş, Meltem Vural, Burcu Önder, and Kadriye Öneş.
    • İstanbul Physical Medicine and Rehabilitation Training and Research Hospital, İstanbul, Turkey
    • Turk J Med Sci. 2020 Jun 23; 50 (4): 994998994-998.

    Background/Aimβ1-selective beta-blockers (BBs) are sympatholytic agents, and discerning their effects on bone health would be of great importance. This study aimed to investigate the influence of β1-selective BBs on bone mineral density (BMD) and fracture risk.Materials And MethodsThis study included postmenopausal women who used β1-selective BBs (BB group) and control group. Sociodemographic characteristics, BMD and previous fragility fractures were recorded. Additionally, the 10-year probability of a major osteoporotic and hip fracture was calculated using the fracture risk assessment tool (FRAX).ResultsA total of 60 participants were included in the study. L1-4 and L2-4 BMD values were significantly higher in BB group than control group (P = 0.015 and P = 0.025, respectively). Moreover, T-scores of lumbar and femur total were significantly higher in the BB group. Two patients in BB and 6 patients in control group had previous fragility fracture. No statistically significant intergroup difference was noted regarding FRAX.ConclusionBased on our results, β1-selective BB usage was associated with higher BMD at the lumbar region in postmenopausal women.This work is licensed under a Creative Commons Attribution 4.0 International License.

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