• Mehmet Erdoğan, Melike Polat, Muhammet Cihat Çelik, Selçuk Öztürk, Serdal Baştuğ, Yunus Emre Özbebek, Salim Neşelioğlu, and Murat Akçay.
• Department of Cardiology, Ministry of Health Ankara City Hospital, Ankara, Turkey
• Turk J Med Sci. 2020 Aug 26; 50 (5): 1323-1329.

Background/AimThis study aimed to determine plasma thiol, disulphide, and serum ischemia-modified albumin (IMA) levels and ferroxidase activity in patients with ascending aorta dilatation (AAD) in comparison to those without AAD and to evaluate the predictive value of these oxidative stress parameters for AAD.Materials And MethodsThis study was designed as a cross-sectional study of 184 patients who applied to our cardiology clinic. Our study population consisted of patients with AAD (n = 85) and without AAD (n = 99). A spectrophotometric method was used to determine plasma thiol, disulphide, and serum IMA levels and ferroxidase activity.ResultsThe native thiol and the total thiol levels were significantly higher in the control group than the AAD group (P < 0.001), whereas the disulphide and IMA levels and the ferroxidase activity were similar between the groups. The native thiol and the total thiol levels were inversely and significantly correlated with ascending aortic diameter (r = –0.38, P < 0.001; r = –0.39, P < 0.001; respectively). The left ventricle mass and the total thiol levels were independent predictors of ascending aortic diameter (β= 0.223, P = 0.02; β= –0.340, P < 0.001; respectively).ConclusionAmong oxidative stress parameters including thiols, disulphide, IMA, and ferroxidase activity, only the lower total thiol levels appear to confer a high risk for AAD development. Along with the proven diagnostic imaging methods, thiol levels may be helpful to diagnose and stratify patients with AAD.This work is licensed under a Creative Commons Attribution 4.0 International License.

29 keywords...

hide…