• Sharique A Ali, Ishrat Naaz, Kamal Uddin Zaidi, and Ayesha S Ali.
• Department of Biotechnology, Saifia Science College, Bhopal (MP)-462001, India.
• Mini Rev Med Chem. 2017 Jan 1; 17 (9): 785-798.

BackgroundSkin pigmentation is a broadly appearing phenomenon in nature which plays an important task of determining the appearance and biology of all vertebrates including human beings. Skin color is a crucial attribute, determined by the synthesis of melanin pigment within melanocytes by the process of melanogenesis and is regulated by many extrinsic as well as intrinsic factors. Tyrosinase catalyzes the key step of melanogenesis, dysfunction of tyrosinase leads to reduce melanin production which results in severe clinical and aesthetical problems of hypopigmentation. Therefore, the regulation of melanin production is an important strategy in the treatment of abnormal skin pigmentation for cosmetic and medicinal purpose.MethodThe present review covers the various aspects of mammalian melanocyte biology which will help in the identification of key regulators of melanogenesis from pharmaceutical and pharmacological point of view. Further sections of the review focus on the dysfunctions of melanogenic pathways, which result in severe clinical and aesthetical problems of hypopigmentation.ConclusionWe have also attempted to highlight the ability of available scientifically validated plant extracts to naturally enhance melanin synthesis in order to cure hypopigmentation.Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

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