• Eur J Prev Cardiol · Dec 2020

    Meta Analysis

    Aspirin for primary prevention of cardiovascular outcomes in diabetes mellitus: An updated systematic review and meta-analysis.

    • Safi U Khan, Zain Ul Abideen Asad, Muhammad U Khan, Swapna Talluri, Farman Ali, Shahzeb KhanMuhammadMDepartment of Internal Medicine, John H Stroger Jr Hospital of Cook County, USA., Ahmad N Lone, Farouk Mookadam, Richard A Krasuski, and Edo Kaluski.
    • Department of Internal Medicine, West Virginia University, USA.
    • Eur J Prev Cardiol. 2020 Dec 1; 27 (19): 2034-2041.

    BackgroundThe safety and efficacy of aspirin for the primary prevention of cardiovascular disease in patients with diabetes mellitus remains controversial.DesignA meta-analysis to investigate the effects of aspirin for the prevention of cardiovascular disease in diabetes mellitus.MethodsTen randomized controlled trials were selected using MEDLINE, EMBASE and CENTRAL databases until 27 September 2018. Risk ratios (RRs) with 95% confidence intervals (CIs) and risk differences (RDs) reported as incident events per 1000 person-years were calculated.ResultsIn 33,679 patients, aspirin did not significantly reduce the risk of major adverse cardiovascular outcomes (RR 0.93, 95% CI 0.87-1.00, P = 0.06; RD -0.68 incident cases per 1000 person-years (95% CI -1.54, 0.17)), cardiovascular mortality (RR 0.95, 95% CI 0.83-1.09, P = 0.49; RD 0.11 incident cases per 1000 person-years (95% CI -0.80, 1.02)), myocardial infarction (RR 0.91, 95% CI 0.75-1.11, P = 0.36; RD -0.66 incident cases per 1000 person-years (95% CI -2.07, 0.75)), or stroke (RR 0.91, 95% C, 0.76-1.10, P = 0.33; RD -0.55 incident cases per 1000 person-years (95% CI -1.57, 0.47)). There was a significantly higher risk of total bleeding associated with aspirin (RR 1.29, 95% CI 1.07-1.55, P = 0.01; RD 1.49 incident cases per 1000 person-years (95% CI 0.36, 2.61)).ConclusionThe use of aspirin for primary prevention of cardiovascular disease in patients with diabetes mellitus increases the risk of total bleeding without reducing the risk of major adverse cardiovascular outcomes.

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