• Life sciences · Jan 1992

    Time-dependent anesthetic and anticonvulsant activities of alphaxalone in Syrian hamsters.

    • S M Guinjoan, D A Golombek, and D P Cardinali.
    • Departamento de Fisiología, Facultad de Medicina, Universidad de Buenos Aires, Argentina.
    • Life Sci. 1992 Jan 1; 51 (26): 2089-95.

    AbstractTo assess whether the anesthetic and anticonvulsant activities of alphaxalone display diurnal variability, groups of Syrian hamsters were studied at 4 h-intervals during a 24 h-cycle. The administration of alphaxalone (5 mg/kg) brought about a greater anesthetic activity (loss of righting reflex) at the middle of the photophase. When assessed in hamsters injected with 3-mercaptopropionic acid, alphaxalone displayed maximal anticonvulsant activity at the 4th of darkness. Evaluation of the time needed for first convulsive response indicated that alphaxalone did not show time-dependent effects, while in control hamsters seizure threshold was low during daylight and attained maximal values at night, showing a peak in seizure threshold at light-dark transition.

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