• Turk J Med Sci · Jun 2020

    Has capsaicin therapeutic benefits in human colon adenocarcinoma? Selection of the most reliable dose via AgNOR.

    • Mustafa Nisari and Recep Eröz.
    • Department of Nutrition and Dietetics, Faculty of Health Science, Nuh Naci Yazgan University, Kayseri, Turkey
    • Turk J Med Sci. 2020 Jun 23; 50 (4): 1076-1081.

    Background/AimTo determine the effect of different doses of capsaicin on AgNOR protein synthesis in human colon adenocarcinoma derivate from colon cancer (Caco-2 cell).Materials And MethodsIn this experimental study, after the cultured of Caco-2 cell line, the cells are divided into 4 groups as control and different capsaicin exposed doses (25uμ, 50uμ, and 75uμ). Mean AgNOR number and total AgNOR area/nuclear area (TAA/NA) were calculated.ResultsA significant differences were detected between control and capsaicin (50uμ) (P = 0.001), between control and capsaicin (75uμ) (P = 0.000), between capsaicin (25uμ) and capsaicin (50uμ) (P = 0.001) and between capsaicin (25uμ) and capsaicin (75uμ) (P = 0.000) for TAA/NA. Also, there were significant differences between control and capsaicin (50uμ) (P = 0.001), between control and capsaicin (75uμ) (P = 0.000), between capsaicin (25uμ) and capsaicin (50uμ) (P = 0.000) and between capsaicin (25uμ) and capsaicin (75uμ) (P = 0.000) for mean AgNOR number.ConclusionA certain amount of capsaicin has a protective effect against colon adenocarcinoma and the dose concentrations are important for the most reliable treatment.This work is licensed under a Creative Commons Attribution 4.0 International License.

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