• Qiang Gao, Huaili Nie, Chunyan Zhu, Naifeng Kuang, Xiaoyu Wang, Yiqian Chen, Xiao Zhang, Dali Zheng, Qing Xia, Tao Yin, Limin Pan, and Liangzhen Xie.
• Taian City Central Hospital.
• Medicine (Baltimore). 2020 Jun 5; 99 (23): e20527.

BackgroundShoulder-hand syndrome (SHS) is a common complication in post-stroke patients. SHS has a large impact on patients and their families, communities, healthcare systems and businesses throughout the world. Non-pharmaceutical therapy for post-stroke SHS is the most common treatment in clinical practice, but their effectiveness is still unclear. The aim of this study is to assess the effect and safety of non-pharmaceutical therapeutic strategies for post-stroke SHS.MethodWe will search 3 in English and 4 in Chinese languages electronic databases regardless of publication date or language. We will include randomized controlled trials (RCTs) assessing the effect of any non-pharmaceutical therapy for post-stroke SHS. Primary outcomes will be any effective instrument for post-stroke SHS. Two authors will independently assess the risk of bias by using Cochrane tool of risk of bias. We will perform network meta-analysis in random effects model to estimate the indirect and mixed effects of different therapeutic strategies by R-3.5.1 software. We will assess the confidence in cumulative evidence by Grading of Recommendations Assessment, Development and Evaluation.ResultsThis study will be to assess the effect and safety of non-pharmaceutical therapy for post-stroke SHS.ConclusionsThis study will assess the effect of different non-pharmaceutical therapeutic strategies for post-stroke SHS and provide reliable evidence for the choice of treatments.Systematic review registration: PROSPERO (CRD42019139993).

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