• Peng-Ju Zheng, Jin-Sheng Wang, Gui-Fang Liu, Shu-Hua Zhang, and Yi-Ying Zhang.
• Department of Otolaryngology, First Affiliated Hospital of Jiamusi University.
• Medicine (Baltimore). 2020 Jun 5; 99 (23): e20557.

BackgroundAlthough previous studies have reported that levocetirizine is utilized for the treatment of children with allergic rhinitis (AR), its conclusions remain inconsistent. This study aims to evaluate the efficacy and harms of levocetirizine for children with AR.MethodsElectronic database sources will be undertaken from the beginning to the present: MEDLINE, EMBASE, The Cochrane Library, CINAHL, ACMD, PsycINFO, Chinese Biomedical Literature Database, and China National Knowledge Infrastructure. We will not apply any restrictions to language and publication status. We will only consider randomized controlled trials of levocetirizine for children with AR. Two authors will independently scan literature, select studies, and collect data. Study quality for each included trial will be assessed using Cochrane risk of bias tool, and statistical analysis will be conducted using RevMan 5.3 software.ResultsThis study will summarize the present evidence to systematically assess the efficacy and harms of levocetirizine for children with AR.ConclusionThe findings of this study intent to adequately inform stakeholders or clinicians, as well as to help develop treatment guidelines.Study Registration NumberINPLASY202040111.

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