• Internal medicine · Jan 2020

    Case Reports

    Acute Interstitial Lung Disease Induced by Rechallenge with Ceritinib.

    • Takamasa Hotta, Tamio Okimoto, Megumi Hamaguchi, Yukari Tsubata, and Takeshi Isobe.
    • Division of Medical Oncology & Respiratory Medicine, Department of Internal Medicine, Shimane University, Japan.
    • Intern. Med. 2020 Jan 15; 59 (2): 253-256.

    AbstractA 40-year-old Japanese man with advanced pulmonary adenocarcinoma harboring anaplastic lymphoma kinase (ALK)-rearranged was administered the selective ALK inhibitor ceritinib as a third-line treatment and continued treatment for nine months. After fourth-line treatment, we performed rechallenge with ceritinib as a fifth-line treatment. On day 54 after rechallenge, the patient developed acutely deteriorating dyspnea. Chest computed tomography showed extensive ground-glass opacities. We diagnosed him with ceritinib-induced interstitial lung disease (ILD) and initiated methylprednisolone pulse therapy. To our knowledge, this is the first report of ceritinib-induced ILD in a Japanese patient. Since it may newly emerge with rechallenge therapy, close attention is necessary.

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