• Tabitha M Cooney, Kenneth J Cohen, Carolina V Guimaraes, Girish Dhall, James Leach, Maura Massimino, Alessandra Erbetta, Luisa Chiapparini, Fatema Malbari, Kim Kramer, Ian F Pollack, Patricia Baxter, Suzanne Laughlin, Zoltán Patay, Young Poussaint Tina T Department of Radiology, Boston Children's Hospital, Boston, MA, USA., and Katherine E Warren.
• Department of Pediatric Oncology, Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Dana-Farber Cancer Institute, Boston, MA, USA.
• Lancet Oncol. 2020 Jun 1; 21 (6): e330-e336.

AbstractOptimising the conduct of clinical trials for diffuse intrinsic pontine glioma involves use of consistent, objective disease assessments and standardised response criteria. The Response Assessment in Pediatric Neuro-Oncology working group, consisting of an international panel of paediatric and adult neuro-oncologists, clinicians, radiologists, radiation oncologists, and neurosurgeons, was established to address issues and unique challenges in assessing response in children with CNS tumours. A working group was formed specifically to address response assessment in children and young adults with diffuse intrinsic pontine glioma and to develop a consensus on recommendations for response assessment. Response should be assessed using MRI of brain and spine, neurological examination, and anti-inflammatory or antiangiogenic drugs. Clinical imaging standards are defined. As with previous consensus recommendations, these recommendations will need to be validated in prospective clinical trials.Copyright © 2020 Elsevier Ltd. All rights reserved.

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