• Massimiliano Bergallo, Linda Ferrari, Giulia Faolotto, Piero E Balbo, Paola Montanari, Filippo Patrucco, Francesco Gavelli, Matteo Daverio, Mattia Bellan, Livia Salmi, Luigi M Castello, and Paolo Ravanini.
• Department of Public Health and Pediatric Sciences, University of Turin Medical School, Turin, Italy.
• Minerva Med. 2020 Jun 1; 111 (3): 245-253.

BackgroundInterferon signature (IS) is the measure of transcripts belonging to pathways of interferon activation. Viral infections can interfere with the interferon pathway, in particular herpesvirus present in immunocompromised hosts. The aim of our study was to evaluate if herpesvirus infections in immunocompromised patients with lower respiratory tract infections (LRTI) could lead to IS alterations.MethodsWe measured IS transcription of six genes on bronchoalveolar lavage of immunocompromised patients with LRTI (IFI27, IFI44, IFIT1, ISG15, RSAD2, SIGLEC1). Patients were divided in three groups based on Epstein-Barr virus (EBV) and other herpesviruses coinfections.ResultsWe included 56 patients, 10 without and 17 with only EBV reactivation (respectively N and E groups) and 29 with EBV and other herpesviruses (group C). IS was higher in group C (P=0.01) compared to other ones, but single gene expressions were different among groups: IFI27 was higher whereas IFIT1 and ISG15 were lower in group C (P<0.05).ConclusionsThe continuous stimulation of interferon cascade by herpesviruses enhances IS. The analysis of IS in immunocompromised population is possible by limiting the use of IFI27, IFIT1, ISG15 genes. Our preliminary results seem to indicate that IS is a useful biomarker of cellular response to herpesvirus infection in immunocompromised patients.

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