• Irene Coloretti, Emanuela Biagioni, Sophie Venturelli, Elena Munari, Martina Tosi, Erika Roat, Lucio Brugioni, Roberta Gelmini, Claudia Venturelli, and Massimo Girardis.
• Department of Anesthesia and Intensive Care, University Hospital of Modena, Modena, Italy.
• J Crit Care. 2020 Oct 1; 59: 37-41.

PurposeTriple therapy with steroids, vitamin C and thiamine has been recently proposed as a safe and beneficial in patients with sepsis. In 2017, we added the use of intravenous vitamin C and thiamine in septic shock patients receiving low dose hydrocortisone because poorly responsive to vasopressors. Aim of this study is to verify whether triple therapy rather than steroids alone can improve outcome in patients with refractory shock.Materials And MethodsIn this before-after retrospective analysis, we compared septic shock patients admitted to our intensive care unit (ICU) who received triple therapy from June 2017 to November 2019 to septic shock patients who received only hydrocortisone from January 2015 to June 2017. Patients of the two study periods were matched 1:1 using a propensity score model.ResultsA final cohort of 56 patients treated with triple therapy were matched to 56 patients treated only with steroids. Triple therapy reduced the length of mechanical ventilation (p = 0,01) and showed a trend in lowering the 30-day and hospital mortality compared to therapy with only hydrocortisone.ConclusionsAlthough with significant limitations, our experience indicated that triple therapy seems to provide an improvement of clinical outcomes in patients with refractory septic shock.Copyright © 2020. Published by Elsevier Inc.

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