• Jian-Long He, Lin Luo, Zhen-Dong Luo, Jian-Xun Lyu, Ming-Yen Ng, Xin-Ping Shen, and Zhibo Wen.
• Department of Radiology, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China; Department of Medical Imaging, Radiology Center, The University of Hong Kong-Shenzhen Hospital, Shenzhen, 518000, China. Electronic address: hejl@hku-szh.org.
• Respir Med. 2020 Jul 1; 168: 105980.

IntroductionChest CT is thought to be sensitive but less specific in diagnosing the 2019 coronavirus disease (COVID-19). The diagnostic value of CT is unclear. We aimed to compare the performance of CT and initial RT-PCR for clinically suspected COVID-19 patients outside the epicentre-Wuhan, China.Materials And MethodsPatients clinically suspected of COVID-19 infection who underwent initial RT-PCR and chest CT at the same time were retrospectively enrolled. Two radiologists with specific training reviewed the CT images independently and final diagnoses of the presence or absence of COVID-19 was reached by consensus. With serial RT-PCR as reference standard, the performance of initial RT-PCR and chest CT was analysed. A strategy of combining initial RT-PCR and chest CT was analysed to study the additional benefit.Results82 patients admitted to hospital between Jan 10, 2020 to Feb 28, 2020 were enrolled. 34 COVID-19 and 48 non-COVID-19 patients were identified by serial RT-PCR. The sensitivity, specificity was 79% (27/34) and 100% (48/48) for initial RT-PCR and 77% (26/34) and 96% (46/48) for chest CT. The image readers had a good interobserver agreement with Cohen's kappa of 0.69. No statistical difference was found in the diagnostic performance between initial RT-PCR and chest CT. The comprehensive strategy had a higher sensitivity of 94% (32/34).ConclusionsInitial RT-PCR and chest CT had comparable diagnostic performance in identification of suspected COVID-19 patients outside the epidemic center. To compensate potential risk of false-negative PCR, chest CT should be applied for clinically suspected patients with negative initial RT-PCR.Copyright © 2020 Elsevier Ltd. All rights reserved.

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