• J. Investig. Med. · Jun 2020

    Review

    CAR-T treatment for hematological malignancies.

    • Shebli Atrash, Kulsum Bano, Bradley Harrison, and Al-Ola Abdallah.
    • Department of Hematologic Oncology and Blood Disorders, Levine Cancer Institute, Charlotte, North Carolina, USA Shebli.Atrash@Atriumhealth.org.
    • J. Investig. Med. 2020 Jun 1; 68 (5): 956-964.

    AbstractChimeric antigen receptor (CAR)-T-cell therapy has sparked a wave of optimism in hematological malignancies, reflected by the successful results of early clinical trials involving patients with pre-B-cell acute lymphoblastic leukemia, B-cell lymphomas and multiple myeloma. CAR-T-cell therapy is considered to be a novel immunotherapy treatment that has the potential for curing certain hematological cancers. However, as use of CAR-T-cell therapy has grown, new challenges have surfaced. These challenges include the process of manufacturing the CAR-T cells, the mechanisms of resistance that underlie disease relapse, adverse effects and cost. This review describes the published results of clinical trials and expected developments to overcome CAR-T resistance.© American Federation for Medical Research 2020. No commercial re-use. See rights and permissions. Published by BMJ.

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