• Rev Med Interne · Nov 2020

    Review

    [Update on beta blockers in 2020].

    • T Bejan-Angoulvant and D Angoulvant.
    • Service de Pharmacologie Médicale, CHRU et Université de Tours. Hôpital Bretonneau, 2 boulevard Tonnellé - 37044 Tours cedex 9, France.
    • Rev Med Interne. 2020 Nov 1; 41 (11): 741-747.

    AbstractBeta-blockers (BB) are an heterogenous set of molecules actively blocking β adrenergic receptors. Their pharmacological properties depend on their various effects on the adrenergic signalling. Although they are no longer a first-choice treatment in hypertensive patients, they remain a cornerstone of pharmacological strategy in several cardiovascular diseases such as stable angina, heart failure, arrythmia and aortic related connective diseases. Beyond their usual non cardiovascular indications such as migraine, hepatic cirrhosis, glaucoma, infantile hemangioma, and hyperthyroidism, new therapeutic fields are under scrutiny. Potential BB therapeutic repurposing is being investigated in COPD and cancer patients. This narrative review first encompasses the basic pharmacological knowledge that may be useful for the clinician. Then it will detail BB main indications before exploring new therapeutic fields.Copyright © 2020. Published by Elsevier Masson SAS.

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