• Rev Assoc Med Bras (1992) · Mar 2020

    Review

    Timing factors as prognostic variables in patients with head and neck squamous cell carcinoma treated with adjuvant radiotherapy: a literature review.

    • Rejane Franco and Gustavo Nader Marta.
    • . Programa de Pós-Graduação, Departamento de Oncologia, Instituto do Câncer do Estado de São Paulo (Icesp), Universidade de São Paulo, São Paulo, SP, Brasil.
    • Rev Assoc Med Bras (1992). 2020 Mar 1; 66 (3): 380-384.

    IntroductionRadiotherapy (RT) plays an important role in the treatment of patients with head and neck neoplasia, and is frequently used as postoperative adjuvant therapy. This study aimed to review the literature about timing factors that may influence the clinical outcomes of patients with advanced head and neck neoplasia treated with adjuvant RT.ResultsTiming factors such as total treatment time, length of adjuvant RT, and the absence of interruptions during RT may influence the clinical outcome of these patients.ConclusionsIn the same way that certain tumor factors can affect the prognosis of patients with squamous cell carcinoma of the head and neck, some therapeutic timing factors are also prognostic factors and therefore, must be carefully orchestrated in order to avoid loss at therapeutic outcomes for these patients.

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