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- Ali Tabatabai, Joseph Rabin, Jay Menaker, Ronson Madathil, Samuel Galvagno, Ashley Menne, Jonathan H Chow, Alison Grazioli, Daniel Herr, Kenichi Tanaka, Thomas Scalea, and Michael Mazzeffi.
- From the Program in Trauma, R Adams Cowley Shock Trauma Center, Department of Medicine.
- A A Pract. 2020 May 1; 14 (7): e01236.
AbstractCritically ill patients with coronavirus disease 2019 (COVID-19) have been observed to be hypercoagulable, but the mechanisms for this remain poorly described. Factor VIII is a procoagulant factor that increases during inflammation and is cleaved by activated protein C. To our knowledge, there is only 1 prior study of factor VIII and functional protein C activity in critically ill patients with COVID-19. Here, we present a case series of 10 critically ill patients with COVID-19 who had severe elevations in factor VIII activity and low normal functional protein C activity, which may have contributed to hypercoagulability.
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