• A&A practice · May 2020

    Case Reports

    Residual Weakness and Recurarization After Sugammadex Administration in Pediatric Patients: A Case Series.

    • Amanda N Lorinc, Katheryne C Lawson, Jonathan A Niconchuk, Katharina B Modes, John D Moore, and Bruce R Brenn.
    • From the Department of Anesthesiology/Division of Pediatric Anesthesiology, Monroe Carell Jr. Children's Hospital at Vanderbilt, Nashville, Tennessee.
    • A A Pract. 2020 May 1; 14 (7): e01225.

    AbstractWhile shown to be safe for administration in pediatric patients, sugammadex has recently been associated with residual weakness or recurarization. We describe 4 additional cases of pediatric patients with residual or recurrent weakness following rocuronium reversal with sugammadex. Two infant patients developed postoperative ventilatory distress, which was possibly related to recurarization after sugammadex reversal. A third patient received sugammadex with apparent waning of clinical effect and subsequently required neostigmine reversal. A fourth patient was observed to have residual weakness, which led to prolonged intubation despite appropriate train-of-four results after reversal with sugammadex.

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