• Corey T Walker, Han Jo Kim, Paul Park, Lawrence G Lenke, Mark A Weller, Justin S Smith, Edward C Nemergut, Daniel M Sciubba, Michael Y Wang, Christopher Shaffrey, Vedat Deviren, Praveen V Mummaneni, Joyce M Chang, Valli P Mummaneni, Khoi D Than, Pedro Berjano, Robert K Eastlack, Gregory M Mundis, Adam S Kanter, David O Okonkwo, John H Shin, Jason M Lewis, Tyler Koski, Daniel J Hoh, Steven D Glassman, Susan B Vinci, Alan H Daniels, Claudia F Clavijo, Jay D Turner, Marc McLawhorn, and Juan S Uribe.
• Department of Neurosurgery, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ.
• Spine. 2020 Jul 1; 45 (13): 911-920.

Study DesignExpert opinion-modified Delphi study.ObjectiveWe used a modified Delphi approach to obtain consensus among leading spinal deformity surgeons and their neuroanesthesiology teams regarding optimal practices for obtaining reliable motor evoked potential (MEP) signals.Summary Of Background DataIntraoperative neurophysiological monitoring of transcranial MEPs provides the best method for assessing spinal cord integrity during complex spinal surgeries. MEPs are affected by pharmacological and physiological parameters. It is the responsibility of the spine surgeon and neuroanesthesia team to understand how they can best maintain high-quality MEP signals throughout surgery. Nevertheless, varying approaches to neuroanesthesia are seen in clinical practice.MethodsWe identified 19 international expert spinal deformity treatment teams. A modified Delphi process with two rounds of surveying was performed. Greater than 50% agreement on the final statements was considered "agreement"; >75% agreement was considered "consensus."ResultsAnesthesia regimens and protocols were obtained from the expert centers. There was a large amount of variability among centers. Two rounds of consensus surveying were performed, and all centers participated in both rounds of surveying. Consensus was obtained for 12 of 15 statements, and majority agreement was obtained for two of the remaining statements. Total intravenous anesthesia was identified as the preferred method of maintenance, with few centers allowing for low mean alveolar concentration of inhaled anesthetic. Most centers advocated for <150 μg/kg/min of propofol with titration to the lowest dose that maintains appropriate anesthesia depth based on awareness monitoring. Use of adjuvant intravenous anesthetics, including ketamine, low-dose dexmedetomidine, and lidocaine, may help to reduce propofol requirements without negatively effecting MEP signals.ConclusionSpine surgeons and neuroanesthesia teams should be familiar with methods for optimizing MEPs during deformity and complex spinal cases. Although variability in practices exists, there is consensus among international spinal deformity treatment centers regarding best practices.Level Of Evidence5.

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