• Ningning Yang, Ming Luo, Shixin Zhao, Wengang Wang, and Lei Xia.
• Institute of Spinal Deformity, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, P. R. China.
• World Neurosurg. 2020 Dec 1; 144: e9-e14.

ObjectiveTo compare the pedicle morphology of nondystrophic scoliosis secondary to neurofibromatosis type 1 (ND-NF1) scoliosis secondary to neurofibromatosis type 1 (NF1-S) and adolescent idiopathic scoliosis (AIS) using computed tomography (CT) in a consistent classification system.MethodsThe transverse pedicle widths of cancellous and cortical channels were measured using preoperative spinal CT images (T1-L5) and then classified as having type A-E pedicles; type B, C, D, and E pedicles were regarded as abnormal. A subset of these patients, a postoperative CT was performed to evaluate the accuracy of pedicle screw placement. According to the perforation of the medial or lateral pedicle walls by the pedicle screw, the placement of screw was classified by a grade ranging from 0 to 3, and grades 2 and 3 were regarded as misplacement.ResultsIn total, 3230 pedicles were measured and classified, and the incidence rate of abnormal pedicles in the ND-NF1 group was significantly greater than that of the AIS group (65.9% vs. 61.4%, P = 0.03). The misplacement rate in the ND-NF1 group was significantly greater than that in the AIS group (12.2% vs. 7.4%; P = 0.01), and in terms of the corresponding 1100 pedicles, the incidence rate of abnormal pedicles in the ND-NF1 group was higher than that in the AIS group (71.7% vs. 64.9%; P = 0.02).ConclusionsThe incidence rate of abnormal pedicles in patients with ND-NF1 is significantly greater than that of patients with AIS, and it may the reason for the higher misplacement rate of pedicle screws in patients with ND-NF1.Copyright © 2020 Elsevier Inc. All rights reserved.

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