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Aust N Z J Obstet Gynaecol · May 1992
Randomized Controlled Trial Comparative Study Clinical TrialA comparison of tiaprofenic acid, mefenamic acid and placebo in the treatment of dysmenorrhoea in general practice.
- M W Tilyard and S M Dovey.
- Department of General Practice, Otago Medical School, Dunedin, New Zealand.
- Aust N Z J Obstet Gynaecol. 1992 May 1; 32 (2): 165-8.
AbstractThe efficiency and side-effects of tiaprofenic acid, mefenamic acid and placebo were compared in the treatment of primary dysmenorrhoea. The trial was a double-blind prospective randomized 3-way crossover study during 6 successive menstrual cycles following a 2-cycle run-in period and involved 50 women with primary dysmenorrhoea selected from 96 volunteers between 16 and 35 years of age. Overall pain was significantly less (p less than 0.05) on treatment with tiaprofenic acid than on treatment with mefanemic acid, placebo, or the women's usual treatments. Both active treatments were well tolerated but more side-effects were reported during treatment with mefenamic acid.
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