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- Guadalupe Melgarejo-Rubio, Sonia M Pérez-Tapia, Emilio Medina-Rivero, and Marco A Velasco-Velázquez.
- Universidad Nacional Autónoma de México, Faculty of Medicine, Pharmacology Department. Mexico City, Mexico.
- Gac Med Mex. 2020 Jan 1; 156 (3): 228-235.
AbstractTherapeutic antibodies are recombinant proteins used in the treatment of cancer. There is a new generation of monoclonal antibodies with activity against cancer cells, known as antibody-drug conjugates. These molecules are made up of three elements: a monoclonal antibody, a highly potent cytotoxic drug, and a chemical linker that binds them together. The antibody recognizes tumor antigens, thereby allowing targeted delivery of the cytotoxic agent to cancer cells. After recognizing its antigen, the antibody-drug conjugate is endocytosed by the target cells, where the protein fraction is degraded into lysosomes, releasing the cytotoxic drug. This article reviews antibody-drug conjugates general characteristics and describes the clinical evidence of efficacy and safety of the first four approved by regulatory agencies in the United States and Europe.Copyright: © 2020 Permanyer.
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