• Israel Parra-Ortega, Noemí Nájera-Martínez, Félix Gaytán-Morales, Iván Castorena-Villa, Catalina Cortés-Flores, Briceida López-Martínez, Vianney Ortiz-Navarrete, and Irlanda Olvera-Gómez.
• Hospital Infantil de México Federico Gómez, Clinical Laboratory Department, Mexico City. Mexico.
• Gac Med Mex. 2020 Jan 1; 156 (3): 187-193.

IntroductionAfter hematopoietic stem cell transplantation (HSCT), natural killer (NK) cells reconstitution is the main barrier against viral infections.ObjectiveTo determine that the knowledge on the kinetics of NK cell reconstitution after HSCT contributes to transplant efficient monitoring, which increases the possibility of its success.MethodTwenty-one patients undergoing HSCT were included, as well as a control group of clinically healthy individuals. At different time points after transplantation (range of 21 to 670 days), CD3- CD16+ CD56+ NK cells were quantified by flow cytometry in peripheral blood samples.ResultsNK cell recovery occurs at three to six months and 10 to 12 months post-transplantation; their number was significantly lower (in comparison with the control group) in the rest of the monitoring time.ConclusionsThe first period of NK cell recovery occurs between three and six months after transplantation. Reconstitution is transient and the number of NK cells varies in the first years.Copyright: © 2020 Permanyer.

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